can you analyze and critique this stack? Longevity Stack Below is a stack inspired by numerous research studies on the compounds therein and their behaviors. The below is for educational purposes only and trying it without being sure about possible side effects / interactions / considerations is definitely not a good idea. Grand Unified Protocol This version moves beyond the four pillars to a more integrated, six-pillar system, explicitly addressing the past omissions. Pillar I: Cellular OS & Rejuvenation (Epigenetics, Senescence, Telomeres, Proteostasis) Pillar II: Metabolic & Energy Engineering (Mitochondria, AMPK/mTOR, NAD+) Pillar III: Neuro-Cognitive Architecture (Neurogenesis, Neurotransmission, Glymphatics) Pillar IV: Systemic & Supracellular Regulation (Endocrine, Immune, Microbiome) Pillar V: Structural Integrity & Integumentary System (NEW): This pillar now formally addresses the aging of the "chassis" - the skeleton, connective tissues, extracellular matrix (ECM), and skin. This is a critical addition for both aesthetics and long-term functional health. Pillar VI: Prophylactic Surveillance & Intervention (NEW): A proactive module for targeting low-probability, high-impact risks like nascent cancer cells. Glossary of Key Terms & Protocols DDFL (Data-Driven Feedback Loop): Using real-time data (Oura, CGM, bloodwork) to make "IF/THEN" adjustments and shift between Protocol States. Protocol States: State 1 (Anabolic): For bodybuilding cycles. State 2 (Maintenance): Default state for cognitive focus and longevity. State 3 (Recovery): Programmed low-intensity state post-senolytics or when DDFL indicates fatigue. RHPN (Rotational High-Performance Nootropic): Daily rotation of potent nootropics. SCS (Strategic Cognitive Sprint): Short-term, high-intensity nootropic stack. VC6TF Chemical Cocktail: An epigenetic reprogramming mixture containing: Valproic acid (500mg), CHIR99021 (5mg), 616452 (RepSox) (5mg), Tranylcypromine (10mg), and Forskolin (20mg). I. The Foundational Protocol: The Core Schedule (Default State 2) Time Pillar Compound & Dosage 06:00 Metabolic Metformin XR 1000mg, SS-31 4mg SubQ, MOTS-c 5mg SubQ, Telmisartan 20mg, Atorvastatin 10mg. (likely would be considering slu-pp-332 here more often than ss-31 and mots-c due to cost. As for the statin, I have low cholesterol so would need to check about avoiding tanking the little cholesterol I have) 06:00 Neuro Adamax 300mcg Nasal, Selank (N-A) 400mcg Nasal, Methylene Blue 2mg Sublingual, Rhodiola Rosea 300mg, 9-Me-BC 15mg Sublingual (4-week cycle). (likely would continue doing subq instead of nasal for most everything, but perhaps nasal would be more convenient in some cases. Nasal irritation just sounds like a possibility idk. As for the 9-me-bc, would check beforehand about whether its metabolites are neurotoxic. I may recall something about that. MAO inhibitors such as Methylene Blue are a long term goal but being put off right now until off things such as bupropion and informed on what kinds of cheeses or something it interacts with as well. May ditch it for things that don't have so many interaction risks.) 07:00 Systemic Testosterone Cypionate 20mg SubQ, 17-alpha-Estradiol 2mg Sublingual, Finasteride 1mg. (likely would use less frequency injections on the trt since only aiming for 100-200mg. Perhaps would do one of the very long esters where can go weeks/months for a base amount like 100mg and then have a shorter ester like cypionate/enanthate for daily/eod use in same syringe as 80iu hcg unless getting onto the new oral hcg thing (ORG *some numbers)) 07:00 Metabolic NMN 500mg, NR 300mg, PQQ 20mg, Idebenone 90mg, SRT2104 (or similar advanced STAC) 150mg, Cycloastragenol 10mg. (Idebenone would replace COQ10 and have broader mitochondrial support apparently. SRT2104 would replace reservatrol and is like 1000x more powerful on Sirt1 apparently. Swim currently has NMN as well as 5 amino 1mq, so am not too worried about NAD+. I hear that there are some stronger NAD+ boosters but I'm fine for now. Cycloastragenol was suggested to me for a more consistent and natural telomerase boost, but I may or may not omit for now since swim would have epitalon. Supposedly cycloastragenol has some immune related activity as well but swim would already have thymosin alpha 1, thymosin beta 4, and thymalin in addition to the epitalon. We'll see. I'll repost periodically if/when the prototocl has had some significant revisions/additions/optimizations.) 07:00 Neuro Lion's Mane (8:1) 1500mg, Alpha-GPC 600mg, Citicoline 500mg, Phosphatidylserine 300mg, 7,8-DHF 25mg, Bacopa 300mg, Centrophenoxine 500mg, SKQ1 Eye Drops, Ginkgo Biloba 120mg, Acetyl-L-Carnitine (ALCAR) 1000mg. (Not sure at the moment why the ai models, which I've been going back and forth for hours over the past few weeks every day, omitted huperzine A 200mcg, Panax Ginseng 400mg, Cordyceps 1000mg, Gotu Kola 750mg, and reishi, but its likely a mix of processing power/context/retrievalAugmentedGeneration dedicated to my given ai prompts, lack of significance compared to the other compounds, and my decreasing amount of time before bed/work/school. I went ahead and dropped the names. This post is mostly about dropping a bunch of names and hypothetical approaches, in an effort to inspire some trains of thought and awareness to anti aging, cognition boosting, and bodybuilding options. This protocol has swim predicted to hit around 140+ IQ on WAIS assessment (like a 10 point boost within the first year and then progress slows down towards a plateau at the 10-20 year point (independent of biomedical advancements that aren't out yet basically such as some of the more advanced gene editing/cellular programming/neural engineering/nanomedicine stuff.)). The rate of aging is predicted at less than 0.5x chronological age. Swim does take a nutrition shake called opticleanse and a couple mild supps like 5 htp and l-tyrosine, dha/epa, k2/d3, that I hasn't been included here but even with just what is included here the lifespan/cognition increase/preservation seems quite significant. Lots of additive value and its hypothetical/theoretical but based off the studies on each of the compound etc. it looks likely. Further optimizations like young blood transfusions and more may be implemented at some point/). 07:00 Structural Nutritional Shake, Creatine 5g, NAC 1000mg, Betaine 1000mg, Astaxanthin 12mg, Ergothioneine 25mg, PEA 600mg, Rosmarinic Acid 400mg, Low-dose Doxycycline 20mg, UC-II Collagen 40mg, High K2 (MK-4/MK-7) 5mg, Hyaluronic Acid 200mg. (I do take a collagen supplement that has types 1-5 and pre/pro biotics and is 10-20g per serving but don't know about UC-II Collagen yet.) 10:00 Neuro **RHPN v3.0 (Rotate Daily):**<br>Dopaminergic: Phenylpiracetam 150mg<br>AMPAkine: IDRA-21 5mg<br>Anxiolytic/Focus: Bromantane 50mg<br>Novel Pathway A: BPN14770 10mg<br>Novel Pathway B: TAK-653 10mg<br>Novel Pathway C: AF710B 5mg<br>Caffeine/L-Theanine 50/100mg.( If anyone has suggestions on what to add here, I am open to it. Some stuff like acd some numbers I have not heard of and I haven't set up a functional web scraper yet for reddit such that I can find what combinations work. When we do get access to that though, I bet us having talked about things a lot will improve its quality and we will have a positive feedback loop.) 12:00 Cellular Spermidine 7.5mg, Urolithin A 500mg, Urolithin B 250mg, Liposomal Curcumin 500mg, Tadalafil 5mg, C3G 250mg, Trehalose 10g. (Taladafil and sildenafil at 25 % of ED dose (5m tadalafil and 25mg sildenafil) apparently had as much benefit on muscle/strength/recovery as 200mg testosterone in one study) 14:00 Neuro NSI-189 40mg (cycled), Cerebrolysin 5mL (cycled), BPC-157 250mcg, Ashwagandha 300mg, Agmatine Sulfate 1000mg, Nicergoline 15mg, Green Tea Extract (EGCG) 400mg, ALCAR 1000mg (2nd dose). (It looks like ALCAR could be confused between acetyl-l-carnitine and acetyl-l-carnosine so something to consider perhaps.) 18:00 Metabolic Metformin XR 1000mg, Berberine 500mg, Benfotiamine 300mg, L-Carnosine 1000mg, Omega-3 3g. (diabetic or nondiabetic... metformin increases lifespan through a number of mechanisms and it hasn't given me any side effects. The Benfotiamine and L-Carnosine by the way are for glycation stuff which has something to do with aging through oxidation or something. The key here is to pay attention to a bunch of different pathways imo. Metformin lets say adds 10% lifespan and fisetin + quercetin lets say adds 5% and eating a bit more vegan lets say adds like 5% (making up that one) and after a bunch of different pathways and mechanisms we may get to very significant/unbelievableAtFirst % increase in lifespan ) 22:00 Structural Topical Tretinoin (0.05%) Topical Estriol (0.1%) cream to 3x weekly. DSIP 100mcg, CJC-1295/Ipamorelin 100/200mcg, Your Sleep Meds, Magnesium, Engineered Probiotic, Glycyrrhizin 80mg (cycled), SKQ1 Eye Drops, Etifoxine 50mg, Low-dose Colchicine 0.3mg. (I read on here about a masculine heterosexual cis gender dude having good results with topical estrogen and it not causing feminization through the way he did it. I'm a bit nervous about it but quite interested. Definitely would have anastrozole/exemestane/tamoxifen etc. on hand when experimenting with topical estrogen or 17-alpha-estradiol. | II. Pulsed, Cyclical & Situational Protocols A. Psychedelic-Assisted Neuroplasticity Protocol (PANP) - Ongoing Schedule: 1 day on, 2 days off with Psilocybin 100-250mcg. (This keeps getting recommended to swim, so here it is. Swim is reluctant about this one due to its fame and wanting to stay out of socially stigmatized stuff moreso at some times in his life more than others. If some dmt or psilocybin can improve his health and academic potential / performance then that is quite appealing to me. Swim is pretty happy with how things are going so is reluctant to "trip" but cognitive enhancement is appealing. In low doses perhaps there would not be the threat of prohibitionists traumatizing swim and hurting them. After seeing some microdosing posts I do wonder how many coworkers and classmates I've interacted with who were on a low dose at the time. I am going to not go on a tangent too much here. I do wonder if it could be a once a week on a Saturday morning thing and the benefits still happen albeit half as fast.) B. Weekly & Monthly Injections Weekly Peptides: Thymosin Alpha-1/Beta-4, GHK-Cu, P21, Dihexa, ARA-290. Weekly Hormones: HCG. Weekly Senomorphic: Rapamycin 10mg (unless in State 1). Monthly Structural Agent: Romosozumab. 210mg SubQ injection, once per month. This is a modern, anabolic osteoporosis drug that builds new bone by inhibiting sclerostin, making it superior for preserving/enhancing facial and skeletal bone density compared to older bisphosphonates. C. Quarterly "Tier X" Senolytic, Purge & Proteostasis Reset Day 1: Rapamycin 10mg. Day 2: Navitoclax 100mg, Dasatinib 100mg, HSP90 Inhibitor (theoretical). (Dasatinib looks like less effort / learning curve to do safely than navitoclax. Navitoclax may warrant blood tests for platelets during and potentially some TPO or something as needed. It may be worth checking if the senescent cells navitoclax targets through bcl-something happen to also be targetable through FOX04-dri and it would actually be easier/cheaper despite FOX04-dir being expensive due to the safety concerns which may warrant expensive blood tests and additional harm reduction substances Day 3: Trametinib 1.0mg, Dasatinib 100mg. (dasatinib and trametinib may add 10% lifespan or so just like fisetin doing 10% whilst not having side effects, but getting that extra 10% lifespan increase involved despite the extra hassle may be worth it. No substance is going to cover all of anti aging and same goes with senolytics for right now apparently.) Days 2-4 (Concurrent): Fisetin 2000mg, Quercetin 1000mg, Ellagic Acid 500mg. Day 4 (Proteostasis Reset): Pulse of Sodium Phenylbutyrate (1000mg) or Mifepristone (25-50mg). Days 5-7 (System Purge): Ivermectin 18mg, Fluconazole 200mg, Rifaximin 550mg BID. Days 8-14: Automatically switch to State 3: Recovery & Detoxification. D. Bi-Annual Deep System Resets January Cycle: Epigenetic Reprogramming & Immune Reconstitution. July Cycle: Precision Senolysis & Telomere Extension. Protocols for both remain as defined in v3.2, including VC6TF, 5-Amino-1MQ, FOXO4-DRI, Epitalon, Thymalin, and IL-7. E. Situational Protocols (As Required) SCS Module: For cognitive sprints (Galantamine, Hydrafinil, Sunifiram). Aggressive Physique "Blast" Cycle (State 1): With RAD-140 and ACE-031. Precision Fat Loss Cycle: With Tirzepatide, Tesofensine, 5-Amino-1MQ. (baller on a budget may do semaglutide instead of tirzepatide. Tesofensine has less withdrawal than clenbuterol apparently, but still some so idk but I hear it can help with studying immensely so perhaps during a study sprint and missing the gym anyway could take advantage of its appetite suppressant effects and be on a mini cut.) Seasonal/Pre-Sun Protocol: Melanotan I (Afamelanotide). A cycle of injections leading up to and during periods of high sun exposure to provide a powerful, protective tan from within, minimizing UV-induced skin aging.(In the south swim mostly be in the house while errybody outside doin they thang. Swim didn't evolve very much sunscreen so.... hehehe. When swim walk from his house to another indoors place swim encounters the sun but briefly and don't feel like applying sunscreen (time and still would miss spots etc.).) F. Prophylactic Surveillance Protocol (Pillar VI) Bi-Annually: Liquid Biopsy (e.g., Galleri test) to screen for cancer-associated circulating DNA. IF/THEN Intervention: IF the liquid biopsy shows any suspicious signals, THEN a cycle of a high-risk, targeted agent like PNC-27 would be considered under strict oncological supervision while pursuing conventional diagnostics. PNC-27 is a research peptide designed to induce apoptosis in certain cancer cells and is held as a purely theoretical, last-resort prophylactic, not a routine supplement. (pnc27 and some other anti cancer peptides might be worth doing here and there in addition to an anti parasitic like ivermectin or an anti fungal. Many supposedly sell for less than the blood tests and don't really have side effects to take into account. There's a ton of anti cancer peptides and some target certain cancers. Idk if pnc27 only targets certain cancers or is just some magical fantasy peptide just sitting around ready to kill cancer (same with thymosin alpha 1). I used to think "if something is too good to be true then it is" but I have had that opinion changed by a number of instances. I'm less quick to mock and make fun of someone now when they say some sci-fi / out there thing lolol. Swim remembers mocking people about peptides, sarms, ai, and a number of other things. Stuff moves quick. We have lives and duties/limited bandwidth.) III. Exhaustive Compound Index & Final Status Compound Status in GUP v4.0 All your original supplements Integrated into Daily Protocol. Core Longevity & Cardio Rapamycin, Metformin, Telmisartan, Atorvastatin, Tadalafil. NAD+ & SIRT1 NMN, NR, Advanced STAC. Mitochondrial Support SS-31, MOTS-c, PQQ, Idebenone (replaces CoQ10), Methylene Blue, ALCAR. Senolytics (Chemical) Dasatinib, Quercetin, Fisetin, Navitoclax, Trametinib, Ellagic Acid. Senolytics (Peptide) FOXO4-DRI. Proteostasis (Anti-aggregate) Centrophenoxine, Trehalose, Sodium Phenylbutyrate/Mifepristone. ECM & Structural Integrity Carnosine, Benfotiamine, Rosmarinic Acid, Doxycycline, Glycyrrhizin, Romosozumab, UC-II Collagen, High K2, Hyaluronic Acid, Tretinoin, Topical Estriol, Melanotan I. Telomere/Thymic Peptides Epitalon, Thymalin. Immune Peptides & Modulators Thymosin Alpha-1/Beta-4, IL-7, Colchicine. Growth/Repair Peptides CJC-1295/Ipamorelin, BPC-157, GHK-Cu. Neurogenic Peptides Adamax, Selank, P21, Dihexa, Cerebrolysin. Cognitive Enhancers (Baseline) Lion's Mane, Choline Sources, 7,8-DHF, Bacopa, Ginkgo, NSI-189. Cognitive Enhancers (Adaptogen) Rhodiola Rosea, Ashwagandha. Cognitive Enhancers (Rotational) Phenylpiracetam, Bromantane, BPN14770, IDRA-21, TAK-653, AF710B. Cognitive Enhancers (Vascular) Nicergoline, Green Tea Extract (EGCG). Cognitive Enhancers (Sprint) Galantamine, Hydrafinil, Sunifiram. Psychedelics Psilocybin. Hormonal Base Testosterone, 17a-Estradiol, HCG, Finasteride. Metabolic Agents Berberine, Tirzepatide, 5-Amino-1MQ, Tesofensine. Glymphatic/Sensory/Joint ARA-290, SKQ1, C3G. Myostatin Inhibitors ACE-031. SARMs RAD-140 / Ostarine (putting rad140/sarms on top of trt is the future I think due to limited androgenicity and higher selectivity compared to the more classic compounds. Supposedly the sarms have less m-tor activity than steroids such as anavar, testosterone, nandrolone, dianabol, and tren. Swim thinks the gains with sarms are quite comparable to those with steroids. Sarms+enclomiphene for 8 weeks can yield some good gains when getting back into things but rad140 20mg + occasional ostarine or lgd-4033 (if dryness from rad 140 develops) + hcg(maintain endogeneous production if desired)/trt will allow gh to remain at non decreased levels (serms lower gh and affect absorption of it as well) and avoid the negative effects of serms that can take a while to develop such as potential ocular and neurotoxicity etc. Prophylactic Oncology PNC-27 (Held in reserve for IF/THEN intervention). (speaking of prophylactics... I think some valocyclovir intermittently can be worth it for reducing viral load of susceptibility to cytomegalovirus/herpes which can accelerate aging apparently) Ancillaries (Reserve) Tamoxifen, Exemestane, Anastrozole, Enclomiphene.